Mostrar el registro sencillo del ítem

Cryptosporidium spp. CP15 and CSL protein-derived synthetic peptides’ immunogenicity and in vitro seroneutralisation capability

dc.creatorAvendaño C.
dc.creatorJenkins M.
dc.creatorMéndez Callejas G.
dc.creatorOviedo J.
dc.creatorPatarroyo M.A.
dc.creatorSánchez Acedo C.
dc.date2019-09-07T16:36:40Z
dc.date2019-09-07T16:36:40Z
dc.date2018
dc.date.accessioned2020-03-04T10:58:50Z
dc.date.available2020-03-04T10:58:50Z
dc.identifierAvendaño, C., Jenkins, M., Méndez-Callejas, G., Oviedo, J., Guzmán, F., Patarroyo, M.A., Sánchez-Acedo, C., Quílez, J. Cryptosporidium spp. CP15 and CSL protein-derived synthetic peptides’ immunogenicity and in vitro seroneutralisation capability (2018) Vaccine, 36 (45), pp. 6703-6710.
dc.identifierhttps://www.scopus.com/search/form.uri?display=basic
dc.identifier10.1016/j.vaccine.2018.09.044
dc.identifier.urihttp://repositorios.rumbo.edu.co/handle/123456789/141183
dc.descriptionCryptosporidium spp. is a zoonotic intracellular protozoan and a significant cause of diarrhoea in humans and animals worldwide. This parasite can cause high morbidity in immunocompromised people and children in developing countries, livestock being the main reservoir. This study was aimed at performing preliminary tests on Swiss albino weaned mice (ICR) to evaluate the humoral immune response induced against peptides derived from Cryptosporidium parvum CP15 (15 kDa sporozoite surface antigen) and CSL (circumsporozoite-like antigen) proteins. Peptides were identified and characterised using bioinformatics tools and were chemically synthesised. The antibody response was determined and the neutralising effect of antibodies was measured in cell culture. Despite all peptides studied here were capable of stimulating antibody production, neutralising antibodies were detected for just two of the CP15-derived ones. Additional studies aimed at evaluating further the potential of such peptides as vaccine candidates are thus recommended.
dc.formatapplication/pdf
dc.formatapplication/pdf
dc.languageeng
dc.relationVaccine;Vol.36, No.45, Oct 29. 2018 páginas 6703-6710
dc.relationhttps://repository.udca.edu.co/bitstream/11158/2104/1/1-s2.0-S0264410X18313136-main.pdf
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/4.0/legalcode.es
dc.rightshttps://www.scopus.com/search/form.uri?display=basic
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightsAtribución-CompartirIgual
dc.sourcehttps://www.scopus.com/search/form.uri?display=basic
dc.subjectCryptosporidium
dc.subjectPéptidos
dc.subjectParásitos
dc.subjectCryptosporidium parvum
dc.subjectCP15
dc.subjectCryptosporidiosis
dc.subjectCryptosporidium
dc.subjectCSL
dc.subjectPeptide
dc.subjectVaccine
dc.titleCryptosporidium spp. CP15 and CSL protein-derived synthetic peptides’ immunogenicity and in vitro seroneutralisation capability
dc.typeArtículo de revista
dc.typeText
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion


Ficheros en el ítem

FicherosTamañoFormatoVer

No hay ficheros asociados a este ítem.

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem